Fellows

 

Sisi Cai, MSC

ESR1 - Leiden University Medical Center (LUMC)

Role of BMP9/endoglin/ALK1 signalling in CLD

Annalisa Addante

ESR2 - Complutense University, Madrid (UMC)

BMP-9 in CLD – in vitro and in vivo studies.

Andrea Malfettone, MSC

ESR3 - IDIBELL, Barcelona


TGF- β and (human) liver stem cells in liver pathologies

Teng Feng, MSC

ESR4 - Univ. of Heidelberg (UH)

Targeting TGF-β signalling in CLD and HCC using compounds derived from fungi

Tatiana Dediulia

ESR5 - Univ- of Heidelberg (UH)


Targeting TGF-β  signalling in CLD and HCC using anti-sense oligonucleotides

Bhavna Rani, MSC

ESR6 - Univ. of Bari Medical School (UB)

Regulating the tumor-host interaction at the immunological and biological level by targeting TGF-β with specific inhibitors

Petra Koudelkova, MSC

ESR7 - Medical University of Vienna (MUW)

Targeting the TGF-β tumour-promoting function in hepatocellular EMT and HCC progression

Claudia Bellomo, MSC

ESR8 - Uppsala University (UU)


Novel inhibitors against EMT and their impact on hepatic carcinoma survival and differentiation

Nemany Abdelhamid Nemany Hanafy, MSC

ESR9 - CNR Nano

Development and production of magneto-fluorescent decorated and TGFβ-inhibitors-loaded microcapsules for delivery into HCC cells.

Yuan Cao

ESR10 - Univ. of Bari Medical School (UB) & GenXPro

Large scale analysis of biomarkers for drug effectiveness of TGF- β inhibitors.

Loubna Chadli, PhD

ER1 - Galapagos BV

Identification of genes that contribute to the development of liver fibrosis.



Rahul Agarwal

ER2 - GenX Pro GmbH

Bioinformatic analysis methods for identification of biomarkers to assess the efficacy of TGF-βRI inhibitors in vivo


Jitka Soukupova

ER3 - IDIBELL, Barcelona

Role of metabolic reprogramming in the effects of TGF-β in liver tumor cells

Justin Crawford

ER1 - Galapagos BV

Microfluidics approach towards a physiologically relevant in vitro liver model

María García Álvaro

ER4 - Leiden University Medical Center (LUMC)

Targeting TGF-beta signaling in HCC

 

Sisi Cai, MSc

Sisi Cai , MScSisi Cai was born in 1988 in China.

She completed her Bachelor’s Degree in Biological Sciencein June, 2010after 4 years’ study in 211 Base Class (a class officially set up by the Ministry of Education of China and with purpose of providing comprehensive training in bioscience and biotech) at the College of Life Sciences, Hunan Normal University, China.

In September, 2010 she started furthering her study for the degree of Msc. in Chemical Biology in the School of Pharmaceutical Sciences, Xiamen University, China. There she has put her main interest in researching the interaction of the orphan nuclear receptor Nur77 and the HBx (hepatitis B virus X protein). She received her Master Degree in June, 2013.

From August, 2013 Sisi Cai started working in Leiden University Medical Center, Netherland as Ph.D student under the supervision of Professor Peter ten Dijke and meanwhile as ESR in the network of IT-LIVER. Her work is centered on TGFβ-associated liver fibrosis and the later-on liver diseases.

2006.09-2010.06     B.Sc, Biological Science, College of Life Sciences, Hunan Normal University, Changsha, China

2010.09-2013.06   M.sc, Chemical Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China

2013.06-Now     Ph.D, TGFbeta signal transduction, Leiden University Medical Center, Netherland

PUBLICATIONS:

  1. Gao, W., Liu, J., Hu, M., Huang, M., Cai, S., Zeng, Z., ... & Zhang, X. K. (2013). Regulation of Proteolytic Cleavage of Retinoid X Receptor-alpha by GSK-3β. Carcinogenesis.

 

 

Annalisa Addante

adante

was born in 1987 in Italy. She completed her Bachelor’s Degree in Healthcare and Pharmaceutical Biotechnology in 2009 at the Faculty of Biotechnology, University of Bari, Bari, Italy. Her bachelor thesis, under the supervision of Dr. Maria Elena Dell’Aquila, concerned the effects of phthalates on parameters of vitality and functionality of the cumulus-oocyte complex on equine. Then she did her Master Degree in Medical Biotechnology at the University of Rome “La Sapienza”. She completed her Master studies in 2011 with an internship concerning “Antagonism of the Angiotensin II receptor Type I and vascular remodelling: role of activation of Ang (1-7) / receptor Mas” in theClinical and Molecular Medicine Department. After this, she worked for six months at the EHS Platform of the Center for Biomolecular Nanotechnology, Italian Institute of Technology (IIT), Arnesano, Lecce, Italy. She is currently working as PhD student in the group of Dr. Aránzazu Sánchez Muñoz at the Department of Biochemistry and Molecular Biology, Universidad Complutense de Madrid (UCM), Madrid, Spain.

 
2009   B.Sc, Healthcare and Pharmaceutical Biotechnology, Faculty of Biotechnology, University of Bari

2011   M.Sc, Medical Biotechnology, University of Rome “La Sapienza”

2012   Collaborator, Center for Biomolecular Nanotechnology, Italian Institute of Technology (IIT)

2013   PhD student, Department of Biochemistry and Molecular Biology, Universidad Complutense de Madrid (UCM), Madrid, Spain

Andrea Malfettone, MSc

Andrea Malfettone, MScAndrea Malfettone was born in Italy, completed his Bachelor’s Degree in Biological Sciences in 2004 and his Master Degree in Biomedical Sciencesin 2007 at the Faculty of Mathematics, Physics and Natural Sciences, University of Bari, Bari, Italy. In 2004 he did his Bachelor Degree internship concerning “Effect of Cariporide on the activation kinetics of the membranous exchanger Na+/H+ in MDA-MB-435 breast cancer cells” under the supervision of Prof. Stephan J. Reshkin at the Department of Bioscience, Biotechnology and Pharmacological Sciences, University of Bari. In 2007 he pursued his Master thesis project focused on “NHERF1 through interaction with EGFR alters its localization and function in breast cancer” at the Department of Bioscience, Biotechnology and Pharmacological Sciences, University of Bari, under the supervision of Prof. Stephan J. Reshkin, in collaboration with the Clinical Experimental Oncology Laboratory, National Cancer Research Centre, Istituto Tumori “Giovanni Paolo II”, Bari, under the supervision of Dr. Angelo Paradiso. In 2011 he attended the Postgraduate Specialization School (5 years course) in Clinical Biochemistry developing the thesis project “Expression analysis of NHERF1 in breast cancer: biological and clinical aspects” at the School of Medicine, Department of Medical Biochemistry, Biology and Physics, University of Bari. He is currently working as PhD student in the group of Dr. Isabel Fabregat, at the Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

Publications

  1. Bellizzi A, Mangia A, Chiriatti A, Petroni S, Quaranta M, Schittulli F, Malfettone A, Cardone RA, Paradiso A, Reshkin SJ. RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease. Int J Mol Med. 2008 Jul;22(1):25-31.
  2. Mangia A, Chiriatti A, Bellizzi A, Malfettone A, Stea B, Zito FA, Reshkin SJ, Simone G, Paradiso A. Biological role of NHERF1 protein expression in breast cancer. Histopathology. 2009 Nov;55(5):600-8.
  3. Mangia A, Tommasi S, Bruno M, Malfettone A, D'Amico C, Zito FA, Paradiso A, Simone G. Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer. Oncol Rep. 2010 Jun;23(6):1641-5.
  4. Simone G, Mangia A, Malfettone A, Rubini V, Siciliano M, Di Benedetto A, Terrenato I, Novelli F, Mottolese M. Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer. J Exp Clin Cancer Res. 2010 Sep 15;29:125.
  5. Bellizzi A, Malfettone A, Cardone RA, Mangia A. NHERF1/EBP50 in Breast Cancer: Clinical Perspectives. Breast Care (Basel). 2010;5(2):86-90.
  6. Mangia A, Malfettone A, Simone G, Darvishian F. Old and new concepts in histopathological characterization of familial breast cancer. Ann Oncol. 2011 Jan;22 Suppl 1:i24-30. Review.
  7. Mangia A, Malfettone A, Saponaro C, Tommasi S, Simone G, Paradiso A. Human epidermal growth factor receptor 2, Na+/H+ exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers. Hum Pathol. 2011 Nov;42(11):1589-95. doi: 10.1016/j.humpath.2011.01.010.
  8. Bellizzi A, Mangia A, Malfettone A, Cardone RA, Simone G, Reshkin SJ, Paradiso A. Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour. Histopathology. 2011 Jun;58(7):1086-95.
  9. Mangia A, Malfettone A, Rossi R, Paradiso A, Ranieri G, Simone G, Resta L. Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation. Histopathology. 2011 Jun;58(7):1096-106.
  10. Malfettone A, Saponaro C, Paradiso A, Simone G, Mangia A. Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis. BMC Cancer. 2012 Mar 22;12:106.
  11. Malfettone A, Silvestris N, Paradiso A, Mattioli E, Simone G, Mangia A. Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype. Exp Mol Pathol. 2012 Jun;92(3):296-303.
  12. Mangia A, Saponaro C, Malfettone A, Bisceglie D, Bellizzi A, Asselti M, Popescu O, Reshkin SJ, Paradiso A, Simone G. Involvement of nuclear NHERF1 in colorectal cancer progression. Oncol Rep. 2012 Sep;28(3):889-94.
  13. Saponaro C, Malfettone A, Ranieri G, Danza K, Simone G, Paradiso A, Mangia A. VEGF, HIF-1α Expression and MVD as an Angiogenic Network in Familial Breast Cancer. PLoS One. 2013;8(1):e53070.

 

Teng Feng, MSc

Teng Feng, MSc Teng Feng was born in 1984 in China. He got his bachelor’s degree of biotechnology  at  2007  and  his  master’s  degree  of  pharmacology  at 2010.

In 2007 he started  his master project “Screening and pharmacological evaluation  of  tumor  vascular  disrupting  agent  (VDA) derives  from Combretastatin  A-4”  at  school  of  medicine  and  pharmacy,  Ocean university  of  China.  In  2008  he  participated  in  the project  “Polymeric immunoglobulin  receptor  in  inflammation-induced  tum or  metastasis of human hepatocellular carcinoma” as an exchange student at Shanghai institute of Materia Medica, Chinese Academy of Sciences.

In 2010 he started his career as an associate scientist at department of oncology, Roche R&D Center (China). His research focus was assessment of new therapeutic targets in liver cancer.

He is currently working as a PhD student at the group of Prof. Steven Dooley at medical faculty Mannheim, Heidelberg University, Germany.

2010.7-2012.5   Associate Scientist, Department of Oncology, Roche R&D Center (China)
2007.9-2010.7   M.S. in Cancer Pharmacology, Ocean University of China
2008.9-2010.7   Exchange student, Shanghai Instituteof Materia Medica, Chinese Academy of Sciences
2003.9-2007.7   B.S. in Biotechnology, Dalian Ocean University

Publications

  1. Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, et al. Bone morphogenetic protein-9 (BMP-9) induces  epithelial  to  mesenchymal  transition  (EMT)  in  hepatocellular  carcinoma  cells. Cancer Sci.2013 Jan 3. doi: 10.1111/cas.12093.(2011 IF: 3.3)
  2. Zhi-ting  Deng*,  Teng  Feng*,  Peng  Wang,  Xin  Qi  et  al.  Effects  of  the  Novel  Vascular Targeting  Agent  MDS-11P  On  Tumor  Vascularity  and  its  Antitumor  Activity.  Biochemical Pharmacology, 2011, 82(12):1832-42 (2011 IF: 4.7) (*Co-first Author)
  3. Jing Ai, Qing-juan Tang, Yan-lin Wu, Yang Xu, Teng Feng, Rui-yu Zhou, Yi Chen et al. The Role of Polymeric Immunoglobulin Receptor in Inflammation-induced Tumor Metastasis of Human  Hepatocellular  Carcinoma.  Journal  of  the  National  Cancer  Institute,  2011, 103(22):1-17. (2011 IF: 13.7)
  4. 4.  Feng Teng, Geng Mei-Yu, Li Jing. Research progress in small molecule vascular disrupting agents. Chinese Journal of New Drugs, 2010,19(24):2285-2289.(in Chinese)
  5. Lin Du, Teng Feng, Boyu Zhao et al. Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities. The Journal of Antibiotics, 2010,63(4):165-70. (2011 IF: 1.6)
  6. Chuan  Rui  Zhang,  Hong  Bing  Liu,  Teng  Feng et  al.  Alkaloids  from  the  Leaves  of Daphniphyllum sub erticillatum.  Journal of Natural Products,  2009,72(9):1669-72. (2011 IF: 3.1)
  7. Xiu  li  Wang,  Teng  Feng,  Lei  Yang  et  al.  dbEST-derived  SSR  markers  in  sea  urchin (Hemicentrotus pulcherrimus). Conservation Genetics, 2008, 10 (3):729-731. (2011 IF:1.6)
  8. Feng  Teng,  Wang  Xiu  Li,  Chang  Ya  Qing.  Research  progress  and applications  of  PCR technology  on  disease  diagnose  in  aquaculture  animal.  Biotechnology  Bulletin, 2006,10(26):62-66.(in Chinese)

 

Tatiana Dediulia

was born in 1986 in Lithuania. She completed her Bachelor´s degree in Bhavna Rani, MSc
Biotechnology in 2009 and her Master´s degree in Molecular Biotechnology in 2010.
Although she is Lithuanian, she has resided in Spain since 1994 therefore she received her primary education in Spain.  She is currently working as Marie Curie Early Stage Researcher (PhD student) in the group of Prof. Steven Dooley at Department of Medicine II, Section Molecular Hepatology, Madical Faculty Mannheim, Heidelberg University, Germany.

In 2007 she participated and collaborated in some Parkinson projects in the Department of Molecular Medicine of University of Salamanca (Salamanca, Spain). One of these projects was awarded with the prize to the best communication at “I National Congress of Investigation for pre-PhD students in Health Science and II Complutense Conferences” of Universidad Complutense de Madrid (University, Madrid, Spain). 

In 2008 she made practices at “Translational and Experimental Oncology group: stem cells, cancer stem cells and cancer”laboratory in the Cancer Research Institute (CIC, Salamanca, Spain).

In 2010 she carried out a final project for her Master degree, “Study of expression and intracellular trafficking of CXCR4 receptor in hepatic carcinoma cells (Hep3B and PLC)” at “Molecular Oncology Laboratory (LOM)” in the Bellvitge Biomedical Research Institute (IDIBELL, Barcelona, Spain), and was recruited at Sant Pau Biomedical Research Institute (Barcelona, Spain) to work in a project called “Study of bad prognosis markers in Head and Neck Squamous Cell Carcinoma (HNSCC) and search for therapeutic alternatives” in the Molecular and Cellular Biology of Cancer group. At that time she also collaborated in a project with Clinical Hematology group.

Educational status

1.         2009-2010: M.Sc. Molecular Biotechnology, Faculty of Pharmacy, University of Barcelona (Spain)

2.         2004-2009: B.Sc. Biotechnology, Faculty of Biology, University of Salamanca (Spain)

Bhavna Rani, MSc

Bhavna Rani, MSc Bhavna Rani is currently working as Marie Curie Early Stage Researcher (PhD student) in the group of Prof. Gianluigi Giannelli at theDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Allergology and Clinical Immunology, University of Bari, Italy. She is an Indian and has received her primary education from India. Later on, she was awarded full scholarship from Dutch ministry of science, education and culture to pursue a specialized Masters in Oncology program at Vrije University (VU) Amsterdam, The Netherlands. She has performed wide array of research projects in the field of molecular and immuno-biology of brain tumors and liver regeneration at different levels in different European countries including the Netherlands, Sweden and Germany. She has been awarded with many International and National Scholarships during her masters studies. She has publications and contributions in peer reviewed journals like Hepatology (2012),Proceedings of National Conference on Genomics, Proteomics & Systems Biology, Indian Institute of Science (IISC), Bangalore, India (2008) andAsPac J. Mol.Biol. Biotechnol (2009). Her research interests include Cancer Immunology, Regenerative medicine and Translational research.

 

Educational status

  1. 2009-2011: Masters of Science (M.Sc.) Oncology VU / VUMC, Amsterdam, the Netherlands.
  2. 2006-2008: M.Sc. Biotechnology, Guru Jambeshwar University of Science and Technology, Hisar, India.
  3. 2003- 2006: B.Sc. Biotechnology, Kurukshetra University, India. 


Awards/Scholarships

  1. December, 2010- 1st June, 2011- Fellowship grant from Oncology Research Lab to undertake Master Thesis Project, Umeå University, Sweden.
  2. December, 2010- 1st June, 2011- Awarded Erasmus Placement Scholarship for six Months to support Master thesis project at Oncology Lab, Umeå University, Sweden.
  3. 2009 - Awarded prestigious “Huygens Scholarship (HSP)” for two years by Dutch Ministry for Education, Science & Culture (Nuffic), The Netherlands.
  4. 2006–2008- Awarded prestigious Department of Biotechnology (DBT), Govt. of India, scholarship for pursuing MSc Biotechnology at GJU, Hisar, India.

 

 

Petra Koudelkova , MSc

Petra Koudelkova , MScPetra Koudelkova was born in  1987 in  Czech Republic. She  achieved her  Bachelor  degree  in 2009  and  subsequent  Master  degree  in  2012 from  Biochemistry  at  the  Faculty  of  Science,  Palacky  University Olomouc, Czech Republic.

In  2008  she  started  her  bachelor  project  “The  Effect  of  N(6)-substituated  adenosine  derivatives  on  proliferation  and  cell  death  in tumour cells” at the Department of Biology, Faculty of Medicine, Palacky University Olomouc which led to obtaining B.Sc. in 2009 (Supervisor Doc. Petr Mlejnek CSc.).

In 2009-2010 she participated on the project  “The Effect of  Dithiocarbamate Complexes in Tumour  Liver  Cell  Lines”  (leader  Mgr.  Boris  Cvek,  Ph.D.)  at  the  Department  of  Molecular Biology and Genetics, Faculty of Science, Palacky University Olomouc.

In  2010-2011  she  gained  an  internship  at  the  world´s  leading  biotechnological  company Amgen (Division Amgen Research GmbH, Regensburg, Germany)  where she started on the beginning  as  an  intern  and  later  as  M.Sc.  student  with  master  project:  “Generation  and characterization  of  stable  expressing  cell  lines  using  different  approaches  for  targeted integration  into  genome  of  mammalian  cells”  (Supervisor  Markus  Hierl,  Dipl.-Ing.,  Cosupervisor Ralf Schwandner, Ph.D.) which led to obtaining M.Sc. in 2012.

Currently, she is working  as Ph.D. student in the group of  Prof. Wolfgang Mikulits  at Institute of Cancer Research, Medical University Vienna, Austria.

2009 – B.Sc. in Biochemistry, Palacky University in Olomouc, Czech Republic
2012 – M.Sc. in Biochemistry, Palacky University in Olomouc, Czech Republic
2013 – Ph.D. Student, Institute of Cancer Research, Medical University Vienna, Austria

Publications:

  1. Dolezel  P,  Koudelkova  P,  Mlejnek  P  (2010)  Halogenation  of  N⁶-benzyladenosine decreases its cytotoxicity in human leukemia cells, Toxicology in Vitro 24(8):2079-83

 

 

Claudia Bellomo, MSc

Claudia Bellomo, MScClaudia Bellomo was born in Italy, completed her Bachelor’s Degree in Healthcare and Pharmaceutical Biotechnology in 2008 and her Master Degree in Medical Biotechnology and Molecular Medicine in 2010 at the Faculty of Biotechnology, University of Bari. In 2008 she did her Bachelor Degree internship concerning “Cloning and expression in yeast gene encoding the protein Lpp2981 of L. Pneumophila Spp.” under the supervision of Dr. Carlo Marya Marobbio at the Pharmaceutical Biological Department, Faculty of Pharmacy, University of Bari. In 2010 she pursued her Master Degree internship focused on “Validation of drug nanocolloids and polyelectrolyte capsules as novel carriers for controlled drug delivery into ovarian cancer cells” at the Nanocarriers and Biomechanics Division of CNR- Nano and Di.Ste.Ba, University of Salento under the supervision of Prof. Susanna Cotecchia, Dr. Stefano Leporatti and Dr. Daniele Vergara. In 2011 she earned a prestigious scholarship given by Elite Network of Bavaria finalized to work as Research Assistant in the group of Prof. Thomas Bein at CENS- Center For Nanoscience, Ludwig Maximilians University, Munich where she dealt with Supported Lipid Bilayer as a pH sensitive cover of silica nanoparticles. She is currently working as PhD student in the group of Prof. Aristidis Moustakas at the Institute for Medical Biochemistry and Microbiology, Uppsala University.

2008    B.Sc, Healthcare and Pharmaceutical Biotechnology, Faculty of Biotechnology, University of Bari
2010    M.Sc, Medical Biotechnology and Molecular Medicine, Faculty of Biotechnology, University of Bari
2012    Research Assistant, Center for Nanoscience, Ludwigs- Maximilians University, Munich, Germany

Publications

  1. Vergara D, Bellomo C, Zhang X, Vergaro V, Tinelli A, Lorusso V, Rinaldi R, Lvov YM, Leporatti S, Maffia M. (2012)Lapatinib/Paclitaxel polyelectrolyte nanocapsules for overcoming multidrug resistance in ovarian cancer. Nanomedicine. 8(6), 891-9
  2. Vergaro V, Scarlino F, Bellomo C, Rinaldi R, Vergara D, Maffia M, Baldassarre F, Giannelli G, Zhang X, Lvov YM, Leporatti S. (2011) Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer cells. Advanced Drug Delivery Review. 63(9), 847-64.

 

 

 

Nemany Abdelhamid Nemany Hanafy, MSc.

Nemany Hanafi, MSc.  Nemany has got Bachelor Degree (with very good grade, 81.2%) in Biological Department -Science collage - Al Azhar University / Assuit. His graduation was in June, 2000. In   May 2002, nemany has studied Master courses   for one full time year (his grade was   very good) for giving him qualification   to apply for MSc research thesis. In May , 2005 , Nemany has applied for MSc degree in Biological Department / Zoology -Science Collage - Al azhar University / Cairo as collaborated   supervision with Cell biological laboratory - Atomic Force Authority . Through his thesis, he investigated the protective role of calcium channel blocker Verapamil against liver fibrosis, Necrosis and steatosis induced by CCl4 + Ethanol.


1996-2000 B.Sc, Biological Science, Science collage, Al azhar University

2002-2003 Pre-MSc, Biological Science, Science collage, Al azhar University

2005-2010 MSc (Researchthesis), Biological Science, Science collage, Al azhar University

2005-Now  Senior Lab, technician, Biological Science, Science Collage, Al azhar university

 

Publications

  1.  Safer, M. Afzal, A.Nomani, O.   Sosamma and Mousa " Curative propensity of green tea extract towards hepatic fibrosis induced by CCl4: A histopathological study" EXPERIMENTAL AND THERAPEUTIC MEDICINE 3: 781-786, 2012
  2. Hanaa Fathy Waer, NomaniAbdel HamidNomani and Eman Rizk Elbealy      "Ameliorated Effects of Verapamil on Hepatotoxicity Induced by Ethanol and Carbon Tetrachloride” J Cytol Histol Volume 3 , Issue 2 , 1000142.
  3. Abdel-Majeedsafer, M.Afzal, M.Nomani, S.A.Mousa "Green Tea Extract in the management of Hepatic Fibrosis” Tea in health and diseases,Elsevier, Chapter 76.

 

 

 

 

Yuan Cao

Yuan Cao

is currently working as PhD student in the group of Prof. Gianluigi Giannelli at the Department of Emergency and Organ Transplantation, Section of Internal Medicine, Allergology and Clinical Immunology, University of Bari. He was born in China, received his Bachelor Degree from Dalian Polytechnic Universityin China and his Master Degreefrom University of Sheffieldin the UK. In 2009, he did hisBachelor graduate project regarding“Analysis of Change of POD and PPO in Oilseed Rape Induced by SclerotiniaScleroterum”. In 2011, he did his Master research project pertaining to “HYDROMAX 1000: A study of surface wetting, anti-algal and anti-fungal properties” under the supervision of Prof. Peter Styring. His research intrests include Drug development &Delivery, Cancer Research, and Organ Transplantation.

2009  BSc Biotechnology, Faculty of Biological and Food Engineering,Dalian Polytechnic University

2011  MSc Biological and Bioprocess Engineering, Department of Chemical and Biological Engineering, Faculty of Engineering, University of Sheffield

 

Loubna Chadli, PhD

Loubna Chadli , MScThis Information will be added shortly !

Rahul Agarwal

Rahul Agarwal

is currently working as experienced researcher (ER) in the GenXPro GmbH, Frankfurt under the supervision of Dr. Peter Winter. He was born in India and received his Bachelor degree in 2004 from Ewing Christian College, India. He did his Master in 2007 from University of Allahabad, India and during Master’s, he done two projects based on Markov’s model. After Master’s, he worked as Lecturer in Bioinformatics at Amity Institute of Biotechnology, Amity University, India. From Dec 2009, he worked as Bioinformatics Research fellow at the Dept. of Animal and Aquacultural Sciences, Norwegian University of Life Sciences (NMBU/UMB), Norway where he executed the project aimed to perform fine mapping of QTL regions affecting boar taint in intact Norwegian male pigs and ascertain underlying genetic variation (SNPs/haplotypes) using combined approach of Whole Genome Re-sequencing, Genotyping and Association Study. His research interests are Bioinformatics, Next Generation Sequencing, Genomics, and Cancer research.

2004               B.Sc., Biology and Chemistry, Ewing Christian College, India

2007               M.Sc., Bioinformatics, University of Allahabad, India

2007-2009      Lecturer (ad-hoc) Bioinformatics, AIB, Amity University, India

2009-2013      Bioinformatics Research Fellow, Dept. of Animal and Aquacultural Sciences,
                      
Norwegian University of Life Sciences (NMBU/UMB), Norway

 

Jitka Soukupova

soukupova

was born in 1986 in the Czech Republic. She completed her Pharmacy Degree at Charles University in Prague in 2010. She obtained an ERASMUS scholarship in 2009 to perform her master thesis at the School of Pharmacy and Pharmaceutical Sciences at Cardiff University titled "Design and synthesis of BCA2 inhibitors" under the supervision of Dr. Andrew D. Westwell. The research had a special interest in organic synthesis of heterocycles as novel inhibitors of BCA2 for a treatment of ER+ breast cancer. She then completed her PhD thesis titled "Bcl-3 inhibitors as a novel therapeutic approach for metastatic breast cancer" at the School of Biosciences, Cardiff, Wales under the supervison of Dr. Richard Clarkson, Dr. Andrea Brancale and Dr. Andrew Westwell.

In October 2014 she joined the group Biological Clues of the Invasive and Metastatic Phenotype at IDIBELL in Barcelona led by Dr. Isabel Fabregat as an Experienced Research under the Marie Curie International Training Network Scheme, in the “Inhibiting TGF-β in liver diseases (IT-Liver)” collaborative project. The specific project is titled "Role of metabolic reprogramming in the effects of TGF-β in liver tumor cells” and aim to define whether EMT induced by TGF-β in hepatocellular carcinoma cells is coincident with metabolic changes and explore the potential correlation with the acquisition of stem cell characteristics.

2010 Pharmacy Degree, The School of Pharmacy, Charles University of Prague, Czech Republic

2013 PhD Degree, The School of Biosciences, Cardiff University, Cardiff, Wales

2014 Postdoctoral Researcher, IDIBELL, Barcelona, Spain

Publications:

1. Alex White; Jitka Soukupova; Andrew D Westwell. Future Science Book Series. Understanding and Exploiting Protein-Protein Interactions as Drug Targets. 04/11/2013.  ISBN 978-1-909453-46-3 Book Chapter

2. Alison Wakefield; Jitka Soukupova; A Montagne; Jill Ranger; Rhiannon French; William J Muller; Richard W Clarkson. Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors. Cancer Research ,73 - 2, pp. 745 - 755. 15/01/2013

3. Ghali Brahemi; Fathima R Kona; Annalisa Fiasella; Daniela Buac; Jitka Soukupova; Andrea Brancale; Angelica Burger; Andrew D Westwell. Exploring the Structural Requirements for Inhibition of the Ubiquitin E3 Ligase Breast Cancer Associated Protein 2 (BCA2) as a Treatment for Breast Cancer. Journal of Medicinal Chemistry. 53 - 7, pp. 2757 – 2765

Justin Crawford

crawford

was born in Canada. He obtained his Honour’s Bachelor of Medical Science Degree in Clinical Biochemistry from the University of Western Ontario in 2009. During his undergraduate degree, he undertook a research project investigating “The roles of Insulin-like Growth Factor Binding Protein 6 (IGFBP-6) in Dupuytren’s Disease” under the supervision of Drs. David O’Gorman and Bing Siang Gan at the Cell and Molecular Biology Laboratory of the Roth/McFarlane Hand and Upper Limb Centre at the Lawson Health Research Institute in London, Canada. In 2009, he was awarded a Canadian Institutes of Health Research Summer Studentship in Musculoskeletal Research and focused on the “Generation of lox-stop-lox POSTN cDNA transgene,” under the supervision of Dr. David O’Gorman. In 2014, he obtained his PhD in Biochemistry from the University of Western Ontario, also under the supervision of Dr. David O’Gorman. His thesis was entitled “The roles of matrix-associated periostin in an in vitro model of hypertrophic scarring.” During his PhD, Justin received the Frederick Banting and Charles Best Canada Scholarship award in 2010 for his work on “periostin in abnormal wound healing,” the Young Investigators Award from the European Tissue Repair Society in 2010 and a Canadian Institutes of Health Research Community Travel Award in 2012. In 2014, he became laboratory manager of the Cell and Molecular Biology Laboratory of the Roth/McFarlane Hand and Upper Limb Centre. There, his focus was on designing and optimizing 3D, mechanical-based assays for studies involving Dupuytren’s Disease and shoulder fibrosis. In 2015 he moved to the Netherlands and is currently working as a Scientist in the New Technology Development team at Galapagos BV.

Education:

2009     BMSc, Clinical Biochemistry, Faculty of Biochemisty, Schulich School of Medicine & Dentistry, University of Western Ontario

2014     PhD, Biochemistry, Faculty of Biochemisty, Schulich School of Medicine & Dentistry, University of Western Ontario

Publications:

Crawford J, Raykha C, Charles D, Gan BS, O'Gorman DB. (2015) WT1 expression is increased in primary fibroblasts derived from Dupuytren's disease tissues. J Cell Commun Signal. [Epub ahead of print]

Crawford J, Nygard K, Gan BS, O'Gorman DB. (2015) Periostin induces fibroblast proliferation and myofibroblast persistence in hypertrophic scarring.Exp Dermatol. Feb;24(2):120-6. doi: 10.1111/exd.12601.

Raykha CN, Crawford JD, Burry AF, Drosdowech DS, Faber KJ, Gan BS, O'Gorman DB (2014) IGF2 expression and β-catenin levels are increased in Frozen Shoulder Syndrome. Clin Invest Med. Aug 1;37(4):E262-7.

Raykha C, Crawford J, Gan BS, Fu P, Bach LA, O'Gorman DB. (2013) IGF-II and IGFBP-6 regulate cellular contractility and proliferation in Dupuytren's disease. Biochim Biophys Acta.Oct;1832(10):1511-9. doi: 10.1016/j.bbadis.2013.04.018.

Raykha C, Crawford J, Gan BS, O'Gorman DB. (2011) Insulin-like Growth Factor Binding Protein (IGFBP)-6: A mediator of myofibroblast differentiation in Dupuytren’s Disease. In: Proceedings of the International Dupuytren’s Symposium. Springer Verlag.

 

María García Álvaro

alvaro

was born in 1988 in Spain. She completed her Bachelor´s Degree in Biology in 2011 and her Master’s Degree in Biochemistry, Molecular Biology and Biomedicine in 2012. Then she continued her career as a PhD student in the group of Dr. Aránzazu Sánchez and Dr. Blanca Herrera at the Department of Biochemistry and Molecular Biology in Universidad Complutense de Madrid (UCM), Madrid, Spain. In 2015 she defended her Thesis entitled “New signals and mechanisms involved in liver cells regulation and their relevance in hepatocarcinogenesis. Role of BMP9 and TGF-β”.

In order to increase her knowledge in the field of TGF-β signaling and liver she joined IT-liver consortium in the group of Peter ten Dijke (LUMC, Leiden, Netherlands) as a post-doctoral Researcher.

Publications

  1. Suárez-Causado A, Caballero-Díaz D, Bertrán E, Roncero C, Addante A, García-Álvaro M, Fernández M, Herrera B, Porras A, Fabregat I, Sánchez A. HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model. Biochim Biophys Acta. 2015 May 20;1853 (10 Pt A):2453-2463. doi: 10.1016/j.bbamcr.2015.05.017. [Epub ahead of print]
  2. Herrera B, García-Álvaro M, Cruz S, et al. BMP9 Is a Proliferative and Survival Factor for Human Hepatocellular Carcinoma Cells. Plos One. 2013;8(7):e69535. doi:10.1371/journal.pone.0069535.
  3. Martínez-Palacián A, del Castillo G, Suárez-Causado A, et al. Mouse Hepatic Oval Cells Require Met-Dependent PI3K to Impair TGF-β-Induced Oxidative Stress and Apoptosis. Plos One. 2013;8(1):e53108. doi:10.1371/journal.pone.0053108.