Original publications

 

Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines.

Dzieran J, Fabian J, Feng T, Coulouarn C, Ilkavets I, Kyselova A, Breuhahn K, Dooley S, Meindl-Beink
PLoS One. 2013 Aug 22;8(8):e72252. doi: 10.1371/journal.pone.0072252. Erratum in: PLoS One. 2014;9(5):e95952.

Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells.
Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, Dzieran J, Li L, Ilkavets I, Kruithof-de Julio M, Munker S, Marx A, Piiper A, Augusto Alonso E, Gretz N, Gao C, Wölfl S, Dooley S, Breitkopf-Heinlein K.
Cancer Sci. 2013 Mar;104(3):398-408. doi: 10.1111/cas.12093.

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.
Dituri F, Mazzocca A, Fernando J, Papappicco P, Fabregat I, De Santis F, Paradiso A, Sabbà C, Giannelli G.
PLoS One. 2013 Jun 27;8(6):e67109. doi: 10.1371/journal.pone.0067109. Erratum in: PLoS One. 2013;8(7). doi:10.1371/annotation/c943a596-3965-4a5b-a27c-55c16685ea32. Peidrò, Fernando Juan [corrected to Fernando, Joan]. PLoS One. 2014;9(6):e100604.

Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation.
Liu Y, Liu H, Meyer C, Li J, Nadalin S, Königsrainer A, Weng H, Dooley S, ten Dijke P.
J Biol Chem. 2013 Oct 18;288(42):30708-19. doi: 10.1074/jbc.M113.478685

Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.

J. Moreno-Càceres, L. Caja, J. Mainez, R. Mayoral, P. Martín-Sanz, R. Moreno-Vicente, M.A. Del Pozo, S. Dooley, G. Egea, I. Fabregat
Cell Death Dis. 2014 Jul 17;5:e1326. doi: 10.1038/cddis.2014.294.

BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation.

García-Álvaro M Addante A, Roncero C, Fernández M,Fabregat I, Sánchez A, Herrera B.
Int J Mol Sci. 2015 Aug 28;16(9):20431-48.  

HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model. 

Suárez-Causado A, Caballero-Díaz D, Bertrán E, Roncero C, Addante A, García-Álvaro M, Fernández M, Herrera B, Porras A,Fabregat I, Sánchez A.
Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2453-63.
 

Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF


Koudelkova, P., Weber, G., and Mikulits, W  . (2015).
PLoS One10:e0142134. 

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma.

T. Feng, J. Dzieran, X. Gu, S. Marhenke, A. Vogel, K. Machida, T.S. Weiss, P. Rümmele, O. Kollmar, P. Hoffmann, F. Graesser, H. Allgayer, J. Fabian, H. Weng, A. Teufel, T. Maass, C. Meyer, U. Lehmann, C. Zhu, P.R. Mertens, C.F. Gao, S. Dooley, N.M. Meindl-Beinker. 
Clinical Science (Lond). 2015;128:761-774. 

A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells. 

Fernando J, Malfettone A, Cepeda EB, Vilarrasa-Blasi R, Bertran E, Raimondi G, Fabra À, Alvarez-Barrientos A, Fernández-Salguero P, Fernández-Rodríguez CM, Giannelli G, Sancho P,Fabregat I. 

Int J Cancer. 2015 Feb 15;136(4):E161-72. doi: 10.1002/ijc.29097. Epub 2014 Aug 4. 

Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma.

P. Reichl, M. Fang, P. Starlinger, K. Staufer, R. Nenutil, P. Muller, K. Greplova, D. Valik, S. Dooley, C. Brostjan, T. Gruenberger, J. Shen, K. Man, M. Trauner, J. Yu, C.F. Gao, W. Mikulits.
Int J Cancer. 2015 Jul 15;137(2):385-94. doi: 10.1002/ijc.29394.
 

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.

López-Luque J, Caballero-Díaz D, Martinez-Palacián A, Roncero C, Moreno-Càceres J, García-Bravo M, Grueso E, Fernández A, Crosas-Molist E, García-Álvaro M, Addante A, Bertran E, Valverde AM, González-Rodríguez Á, Herrera B, Montoliu L, Serrano T, Segovia JC, Fernández M, Ramos E, Sánchez A,Fabregat I. Hepatology. 2016 Feb;63(2):604-19. doi: 10.1002/hep.28134. Epub 2015 Oct 10.

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Carthy JM, Stöter M, Bellomo C; Vanlandewijck M, Heldin A, Morén A, Kardassis D, Gahman TC, Shiau AK, Bickle M, Zerial M, Heldin CH, Moustakas A.
Sci Rep. 2016 Jul 19;6:29868. doi: 10.1038/srep29868. 

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men. 

Dropmann A, Dediulia T, Breitkopf-Heinlein K, Korhonen H, Janicot M, Weber SN, Thomas M, Piiper A, Bertran E, Fabregat I, Abshagen K, Hess J, Angel P, Coulouarn C, Dooley S, Meindl-Beinker NM.
Oncotarget. 2016 Apr 12;7(15):19499-518. doi: 10.18632/oncotarget.6967.

Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression.

 

Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, Xu C, Yu C, Li Q, Meyer C, Ilkavets I, Müller A, Stump-Guthier C, Munker S, Liebe R, Zimmer V, Lammert F, Mertens PR, Li H, Ten Dijke P, Augustin HG, Li J, Gao B, Ebert MP, Dooley S, Li Y, Weng HL. 

Am J Pathol. 2016 Jul;186(7):1874-89. doi: 10.1016/j.ajpath.2016.03.010.

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes.

Chen S, Feng T, Maja VS, Altamura S, Breitkopf-Heinlein K, Altenoder J, Weiss TS, Dooley S, Muckenthaler MU.
J Biol Chem. 2016 Jun 17;291(25):13160-74. doi: 10.1074/jbc.M115.691543. 

Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice.

S. Karkampouna, M.J. Goumans, P. Ten Dijke, S. Dooley, M. Kruithof-de Julio.
Arch Toxicol. 2016 Feb;90(2):347-57

Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1.
Moreno-Càceres J, Mainez J, Mayoral R, Martín-Sanz P, Egea G, Fabregat I.
FEBS J. 2016 Apr;283(7):1300-10. doi: 10.1111/febs.13669

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.

Govaere, O.,Wouters, J.,Petz, M. ,Vandewynckel, Y.P.,Van den Eynde, K. ,Van den Broeck, A.,Verhulst, S .,Dollé, L.,Gremeaux, L .,Ceulemans, A .,Nevens,F.,van Grunsven, L.A .,Topal, B .,Vankelecom, H ,Giannelli, G .,Van Vlierberghe, H.,Mikulits, W,Komuta, M ., andRoskams, T . (2016).
J. Hepatol.64, 609-617

Glypican-3 promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through ERK signaling pathway.

Y. Wu, H. Liu, H. Weng, X. Zhang, P. Li, C.L. Fan, B. Li, P.L. Dong, L. Li, S. Dooley, H.G. Ding.
Int J Oncol. 2015 Mar;46(3):1275-85. doi: 10.3892/ijo.2015.2827.

Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice

Nadja Meindl-Beinker, Teng Feng, Johanna Dzieran, Xiaodong Yuan, Thorsten Maass, Andreas Teufel, Silke Marhenke, Timo Gaiser, Felix Rückert, Ingo Kleiter, Stephan Kanzler, Matthias Ebert, Arndt Vogel, Peter ten Dijke, Steven Dooley, and Anne Dropmann
[Paper #ONCSIS-16-0205R], Oncogenesis, in press

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.

Eva Crosas-Molist, Esther Bertran, Irene Rodriguez-Hernandez, Cecilia Herraiz, Gaia Cantelli, Àngels Fabra, Victoria Sanz-Moreno, Isabel Fabregat.
Oncogene 2016 Dec 12. doi: 10.1038/onc.2016.454. [Epub ahead of print]