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Precision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study.

Agarwal R, Cao Y, Hoffmeier K, Krezdorn N, Jost L, Meisel AR, Jüngling R, Dituri F, Mancarella S, Rotter B, Winter P, Giannelli G.

Cell Death Dis. 2017 Jun 8;8(6):e2867. doi: 10.1038/cddis.2017.229.

NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC.

Cao Y, Agarwal R, Dituri F, Lupo L, Trerotoli P, Mancarella S, Winter P, Giannelli G.

Cell Death Dis. 2017 Feb 23;8(2):e2634. doi: 10.1038/cddis.2017.44.

Transforming Growth Factor-β Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells.

Koudelkova P, Costina V, Weber G, Dooley S, Findeisen P, Winter P, Agarwal R, Schlangen K, Mikulits W.

Int J Mol Sci. 2017 Oct 10;18(10). pii: E2119. doi: 10.3390/ijms18102119.

The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells.

Moreno-Càceres J, Caballero-Díaz D, Nwosu ZC, Meyer C, López-Luque J, Malfettone A, Lastra R, Serrano T, Ramos E, Dooley S, Fabregat I.
Cell Death Dis. 2017 Oct 12;8(10):e3098. doi: 10.1038/cddis.2017.469.

Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.

Soukupova J, Malfettone A, Hyroššová P, Hernández-Alvarez MI, Peñuelas-Haro I, Bertran E, Junza A, Capellades J, Giannelli G, Yanes O, Zorzano A, Perales JC, Fabregat I.
Sci Rep. 2017 Oct 2;7(1):12486. doi: 10.1038/s41598-017-12837-y.

Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFβ inhibitors to hepatocellular carcinoma cells.

Hanafy NAN, Quarta A, Di Corato R, Dini L, Nobile C, Tasco V, Carallo S, Cascione M, Malfettone A, Soukupova J, Rinaldi R, Fabregat I, Leporatti S.
J Mater Sci Mater Med. 2017 Aug;28(8):120. doi: 10.1007/s10856-017-5930-7. Epub 2017 Jul 6.

Transforming growth factor-β-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma.

Malfettone A, Soukupova J, Bertran E, Crosas-Molist E, Lastra R, Fernando J, Koudelkova P, Rani B, Fabra Á, Serrano T, Ramos E, Mikulits W, Giannelli G, Fabregat I.
Cancer Lett. 2017 Apr 28;392:39-50. doi: 10.1016/j.canlet.2017.01.037. Epub 2017 Feb 2.

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.

Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A.
Cell Death Differ. 2017 Dec 11. doi: 10.1038/s41418-017-0021-3. [Epub ahead of print]

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.

Mathot L, Kundu S, Ljungström V, Svedlund J, Moens L, Adlerteg T, Falk-Sörqvist E, Rendo V, Bellomo C, Mayrhofer M, Cortina C, Sundström M, Micke P, Botling J, Isaksson A, Moustakas A, Batlle E, Birgisson H, Glimelius B, Nilsson M, Sjöblom T.
Cancer Res. 2017 Apr 1;77(7):1730-1740. doi: 10.1158/0008-5472.CAN-16-1921. Epub 2017 Jan 20.

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Carthy JM, Stöter M, Bellomo C, Vanlandewijck M, Heldin A, Morén A, Kardassis D, Gahman TC, Shiau AK, Bickle M, Zerial M, Heldin CH, Moustakas A.
Sci Rep. 2016 Jul 19;6:29868. doi: 10.1038/srep29868

BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration.

Herrera B, Addante A, Sánchez A.
Int J Mol Sci. 2017 Dec 23;19(1). pii: E39. doi: 10.3390/ijms19010039. Review.

BMP-9 interferes with liver regeneration and promotes liver fibrosis.

Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel M, Ehlting C, Bode JG, Müller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin H, Sánchez A, Dooley S, Ten Dijke P.
Gut. 2017 May;66(5):939-954. doi: 10.1136/gutjnl-2016-313314. Epub 2017 Mar 23.

Resminostat induces changes in epithelial plasticity of hepatocellular carcinoma cells and sensitizes them to sorafenib-induced apoptosis.

Soukupova J, Bertran E, Peñuelas-Haro I, Urdiroz-Urricelqui U, Borgman M, Kohlhof H, Fabregat I.

Oncotarget. 2017 Nov 30;8(66):110367-110379. doi: 10.18632/oncotarget.22775. eCollection 2017 Dec 15.

 
Abdel‑Majeed Safer, Mohamad Afzal, Nemany Hanafy and Shaker Mousa
DOI: 10.3892/etm.2014.2158

He G, Dhar D, Nakagawa H, Font-Burgaa J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M.
Cell. 2013 Oct 10;155(2):384-96. doi: 10.1016/j.cell.2013.09.031.

Combinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, including follistatin. 
 
Leutner S, Oliveira KC, Rotter B, Beckmann S, Buro C, Hahnel S, Kitajima JP, Verjovski-Almeida S, Winter P, Grevelding CG.
PLoS Negl Trop Dis. 2013 Nov 7;7(11):e2532. doi: 10.1371/journal.pntd.0002532. eCollection 2013.

Underlying potential: cellular and molecular determinants of adult liver repair

Anna Mae Diehl, John Chute
JCI; May 1, 2013; Volume 123, issue 5

Liver sinusoidal endothelial cells and liver regeneration

Laurie D. DeLeve
JCI; May 1, 2013; Volume 123, issue 5

Differentiation of progenitors in the liver: a matter of local choice

Luke Boulter, Wei-Yu Lu, Stuart J. Forbes
JCI; May 1, 2013; Volume 123, issue 5

Hepatic stem cell niches

Claus Kordes, Dieter Häussinger
JCI; May 1, 2013; Volume 123, issue 5

Sox9 and programming of liver and pancreatic progenitors

Yoshiya Kawaguchi
JCI; May 1, 2013; Volume 123, issue 5

Evolving therapies for liver fibrosis

Detlef Schuppan, Yong Ook Kim
JCI; May 1, 2013; Volume 123, issue 5

Hepatic stellate cells in liver development, regeneration, and cancer

Chunyue Yin, Kimberley J. Evason, Kinji Asahina, Didier Y.R. Stainier
JCI; May 1, 2013; Volume 123, issue 5

Cancer stem cells in the development of liver cancer

Taro Yamashita, Xin Wei Wang
JCI; May 1, 2013; Volume 123, issue 5

Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines

 

Dzieran J, Fabian J, Feng T, Coulouarn C, Ilkavets I, Kyselova A, Breuhahn K, Dooley S, Meindl-Beinker NM.

PLoS One. 2013 Aug 22;8(8):e72252. doi: 10.1371/journal.pone.0072252.

Zonation of Nitrogen and Glucose Metabolism Gene Expression upon Acute Liver Damage in Mouse

 

Ghafoory S, Breitkopf-Heinlein K, Li Q, Scholl C, Dooley S, Wölfl S.

PLoS One. 2013 Oct 17;8(10):e78262. doi: 10.1371/journal.pone.0078262.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

 

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23.

Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells

 

Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K.

J Clin Invest. 2013 Jul 1;123(7):2832-49. doi: 10.1172/JCI65859. Epub 2013 Jun 10.

Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4

 

Gobejishvili L, Barve S, Breitkopf-Heinlein K, Li Y, Zhang J, Avila DV, Dooley S, McClain CJ.

J Pharmacol Exp Ther. 2013 Oct;347(1):80-90. doi: 10.1124/jpet.113.204933. Epub 2013 Jul 25.

IFN-γ inhibits liver progenitor cell proliferation in HBV-infected patients and in 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-fed mice

 

Weng HL, Feng DC, Radaeva S, Kong XN, Wang L, Liu Y, Li Q, Shen H, Gao YP, Müllenbach R, Munker S, Huang T, Chen JL, Zimmer V, Lammert F, Mertens PR, Cai WM, Dooley S, Gao B.

J Hepatol. 2013 Oct;59(4):738-45. doi: 10.1016/j.jhep.2013.05.041. Epub 2013 Jun 4.

Caveolin and TGF-β entanglements

Meyer C, Liu Y, Dooley S.

J Cell Physiol. 2013 Nov;228(11):2097-102. doi: 10.1002/jcp.24380. Review.

Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes

Meyer C, Dzieran J, Liu Y, Schindler F, Munker S, Müller A, Coulouarn C, Dooley S.
Cell Commun Signal. 2013 Jan 22;11(1):6. doi: 10.1186/1478-811X-11-6.

Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis

Meyer C, Liu Y, Kaul A, Peipe I, Dooley S.

Cell Death Dis. 2013 Jan 17;4:e466. doi: 10.1038/cddis.2012.204.

Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells

Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, Dzieran J, Li L, Ilkavets I, Kruithof-de Julio M, Munker S, Marx A, Piiper A, Augusto Alonso E, Gretz N, Gao C, Wölfl S, Dooley S, Breitkopf-Heinlein K.

Cancer Sci. 2013 Mar;104(3):398-408. doi: 10.1111/cas.12093. Epub 2013 Feb 13.